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Table 2 Associations between the combined effects of high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) levels with the risk of dementia

From: High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study

Combined effect of hs-CRP and HbA1c

Numbers

Event

PYs

Crude model

Adjusted model †

 

HR (95% CI)

P value *

HR (95% CI)

P value *

High levels of both hs-CRP and HbA1c

756

32

5850

5.69 (3.08 ~ 10.51)

< 0.001

2.36 (1.20 ~ 4.62)

0.012

High level of only hs-CRP

682

19

5408

3.66 (1.86 ~ 7.19)

< 0.001

2.58 (1.29 ~ 5.17)

0.007

High level of only HbA1c

772

40

6082

6.85 (3.79 ~ 12.40)

< 0.001

2.52 (1.34 ~ 4.74)

0.004

Non-high levels in both

1903

15

15,586

1.00

 

1.00

 
  1. PYs person-years, HR hazard ratio, CI confidence interval
  2. *Analyzed using Cox proportional hazards regression analyses
  3. †Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, triglycerides, body mass index, exercise status, smoking status, alcohol consumption, heart diseases, stroke, and chronic infection or inflammation
  4. ‡Cutoff points for a high level of hs-CRP and HbA1c were based on the 66th percentiles: hs-CRP ≥0.15 mg/dL and Hba1c ≥5.60%
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Immunity & Ageing

ISSN: 1742-4933

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