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Table 3 β (95%CIs) of the associations of C-reactive protein and white blood cell with frailty progression stratified by age

From: C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study

 

CRP

WBC

 

Model1

Model2

Model1

Model2

 

β (95% CI)

β (95% CI)

β (95% CI)

β (95% CI)

<60 years (n = 5217)

 Q1 × Time

Reference

Reference

Reference

Reference

 Q2 × Time

0.020(−0.093, 0.134)

0.025(−0.097, 0.147)

0.032(− 0.084, 0.149)

0.038(− 0.087, 0.163)

 Q3 × Time

0.069(− 0.046, 0.183)

0.065(− 0.058, 0.188)

0.086(− 0.030, 0.203)

0.087(− 0.038, 0.212)

 Q4 × Time

0.244 (0.129, 0.359)

0.245 (0.121, 0.368)

0.163 (0.048, 0.279)

0.168 (0.044, 0.293)

 P for Trend

< 0.001

< 0.001

0.003

0.005

 Continuous variable ×Time

0.241 (0.135, 0.347)

0.239 (0.125, 0.353)

0.717 (0.297, 1.138)

0.729 (0.277, 1.180)

≥60 years (n = 3894)

 Q1 × Time

Reference

Reference

Reference

Reference

 Q2 × Time

0.080(−0.094, 0.255)

0.082(− 0.109, 0.274)

0.026(− 0.150, 0.203)

0.012(− 0.181, 0.206)

 Q3 × Time

0.043(− 0.132, 0.219)

0.029(− 0.164, 0.222)

−0.004(− 0.181, 0.173)

−0.011(− 0.205, 0.183)

 Q4 × Time

0.116(− 0.062, 0.293)

0.101(− 0.093, 0.296)

0.036(− 0.142, 0.214)

0.038(− 0.157, 0.232)

 P for Trend

0.289

0.423

0.764

0.744

 Continuous variable ×Time

0.113(−0.047, 0.274)

0.096(−0.080, 0.272)

0.112(− 0.544, 0.768)

0.125(− 0.594, 0.843)

  1. Q1 as the lowest quartile and Q4 as the highest quartile. CRP and WBC as continuous variables were log transformed
  2. In < 60 years, age range was 45–59 years, and CRP quartile categories at baseline were as follows: < 0.50, 0.50–0.89, 0.90–1.79, 1.80–10.00 mg/L; WBC quartile categories at baseline were as follows: 4.0–5.0, 5.1–5.9, 6.0–7.0, 7.1–10.0 109/L
  3. In ≥60 years, age range was 60–95 years, and CRP quartile categories at baseline were as follows: < 0.61, 0.61–1.10, 1.11–2.15,2.16–10.00 mg/L; WBC quartile categories at baseline were as follows: 4.0–5.0, 5.1–5.9, 6.0–6.9, 7.0–10.0 109/L
  4. β (95% CI) was calculated by linear mixed-effect models and presented as multiply by 102. Model 1: adjusted for age, sex, education level, marital status, smoking status, drinking status, residence, and body mass index; Model 2: additionally adjusted for frailty index at baseline
  5. CRP C-reactive protein, WBC white blood cell
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Immunity & Ageing

ISSN: 1742-4933

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