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Table 1 The hormesis activity of natural compounds in vivo in adaptive responses of mitochondria

From: Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Activity

Compound

Source Plant

Model

Treatment

Remarks

Reference

Adaptive responses of mitochondria

Berberine

Coptidis rhizome, Hydrastis canadensis

Rat

10 μM

Berberine exerts mitohormesis activity

[44]

Polyphenol

Ribes nigrum

Mice

200 mg/kg

Polyphenol increases homeostasis and mitochondrial biogenesis

[46]

Curcumin

Curcuma longa

Rat

15 mg/kg

The low dose was effective

[47]

Curcumin with hesperidin

Curcuma longa

Rat

Curcumin (50, 100 mg/kg), hesperidin (10, 25 mg/kg)

Both compounds improve mitochondrial enzymes and reduce apoptosis

[48]

Resveratrol

Ribes nigrum

Mice

10 mg/kg

Resveratrol exerts mitohormesis activity

[51]

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Immunity & Ageing

ISSN: 1742-4933

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