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Fig. 5 | Immunity & Ageing

Fig. 5

From: Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways

Fig. 5

Effects of Bb, Lp, and LB on the cognitive function in aged mice. a Effects on spontaneous alternation in the Y-maze task. Effects on hippocampal BDNF (b), TNF-α (c), IL-6 (d), IL-1β (e), and IL-10 (f) expression, TNF-α to IL-10 expression ratio (g), and IL-6 to IL-10 expression ratio (h), assessed by qPCR. Effects on BDNF+NeuN+ (i) and NF-κB+Iba1+ cell populations (j). (k) Effects on p-FOXO3a and FOXO3a expression, assessed by immunoblotting. Effects on blood endotoxin (l) and corticosterone levels (m). Bb, Lp, and LB (1 × 109 CFU/mouse/day) and Cr (75 mg/kg) were orally gavaged once a day (6 days in one week) for 8 weeks. Data are indicated as mean ± SD (n = 6). #p < 0.05 vs. Yg. *p < 0.05 vs. Vh/Ag

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Immunity & Ageing

ISSN: 1742-4933

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