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Table 1 Characteristics of VITAL cohort participants included in this study

From: Frailty is related to serum inflammageing markers: results from the VITAL study

 

Total

Young (25–49 years)

Middle age (50–64 years)

Older (≥ 65 years)

N

317

63

95

159

Age median (IQR)

65 (54–75)

35 (29–42)

58 (55–61)

75 (69–81)

Sex % female

54

67 a

59

47

BMI kg/m2, median (IQR)

24.6 (22.4–27.5)

24.0 a b (21.5–25.5)

24.0 (21.8–26.5)

25.3 (23.4–28.6)

CMV %positive / %negative

48/51

42/57

51/47

50/48

EBV %positive / %negative

83/14

76/18

87/13

83/13

Smoking, %smoking > 4 cigarettes/week

3.7

1.6

3.2

5.0

Frailty index median (IQR)

0.13 (0.08–0.20)

0.06 a b (0.03–0.10)

0.10 c (0.06–0.14)

0.18 (0.13–0.26)

EQ-5D-3L median (IQR)

1 (0.81–1)

1 a (0.84–1)

1 c (0.84–1)

0.84 (0.81–1)

SF-36 PF median (IQR)

95 (80–100)

100 a b (95–100)

95 c (90–100)

85 (65–95)

SF-36 HG median (IQR)

70 (60–80)

75 a (70–85)

75 c (65–85)

65 (55–75)

Health rating median (IQR)

8.0 (7.0–8.5)

8.0 (7.5–9.0)

8.0 (7.5–9.0)

8.0 (7.0–8.5)

Number of medications median (IQR)

2 (0–4)

0 a (0–1)

1 c (0–2)

4 (2–6)

  1. asignificantly different between Young and Older groups
  2. bsignificantly different between Young and Middle age groups
  3. csignificantly different between Middle age and Older groups. For the characteristics of the Frailty Index, see Supplementary Table S1. IQR inter-quartile range, BMI body mass index, CMV Cytomegalovirus, EBV Epstein-Barr virus, EQ-5D-3L EuroQol-5 Dimensions-3 Level, SF-36 short-form-36, PF physical functioning, HG general health. In some cases, the percentage of CMV and EBV positive and negative participant do not add up to 100%, which is due to participants at borderline antibody concentrations (between ≥ 4 and < 7.5 RU/mL for CMV; ≥ 16 and 22 RU/mL for EBV)