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Fig. 1 | Immunity & Ageing

Fig. 1

From: Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people

Fig. 1

CD8+ T cell senescence and COVID-19 infection. The COVID-19+ cohort (blue violin plot) was compared with the control cohort (grey violin plot) for the following parameters: (A) Lymphocyte and CD8+ T cell counts, (B) CD8 senescence markers characterized by percentage of CD27−CD28−, EMRA, CD57+, KLRG1+, CD56+, NKG2a+ among CD8+ T cell and normalized mean fluorescence intensity of Sestrine-2 (Sesn-2) expression in CD8+ T cell, (C) CD8+ T cell differentiation stages i.e. naïve, T stem cell memory (TSCM), effector memory (EM), central memory (CM) and EMRA percentages among CD8 + T cells and (D) A correlation matrix of these parameters. A red rectangle denotes the CD8 senescence profile. Two-group differences were tested using a two-sided unpaired t-test. The difference was considered as significant when the p-value was equal to or under 0.05. The p-values are summarized with asterisks (< 0.05*, < 0.01**, < 0.001***, < 0.0001****, ns non significant)

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Immunity & Ageing

ISSN: 1742-4933

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