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Fig. 4 | Immunity & Ageing

Fig. 4

From: Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy

Fig. 4

Irisin attenuates tau-induced mitochondrial dysfunction. (A-B) Representative transmission electron (TEM) micrographs showing mitochondrial morphology in the hippocampus (Α) and the proportion of each type of mitochondria (B). Class I: mitochondria with intact cristae; Class II: swollen mitochondria with vacuolation in the cristae. Scale bar, 500 nm. N = 20 analyzed fields from 3 mice for each group. (C-D) SOD activity and MDA contents in the hippocampus. N = 5 mice for each group. (E-F) Representative TEM micrographs showing mitochondrial morphology in BV2 cells (E) and the proportion of mitochondria subclasses (F). Scale bar, 500 nm. N = 20 analyzed fields from 3 independent experiments. (G-H) Representative images (G) and quantitation (H) of TMRE and MitoSox Red fluorescence in BV2 cells. N = 6 independent experiments. Data were expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Immunity & Ageing

ISSN: 1742-4933

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