Fig. 2

Differences in cell compositions across four conditions. A, UMAP projection of the Control, E-NoSEP, Y-SEP, E-SEP conditions. Each dot corresponds to a single cell, colored according to cell type.  B, The bar plot shows the average proportion of each cell type derived from different groups of patients.  C, Heatmap represents cluster preference across four conditions estimated by Ro/e score. One cluster is identified as being enriched in a condition if Ro/e>1. D, The top dot plot shows the sum of absolute counts of lymphocytes and monocytes in the PBMCs of each sample. The bottom bar plot shows the relative contribution of each cluster in each studied subject. E, The percentage of major immune cell types across four conditions. Conditions are shown in different colors. Horizontal lines represent median values, with whiskers extending to the furthest data point within a maximum of 1.5 × interquartile range. All differences with P < 0.05 are indicated. *P < 0.05, **P < 0.01; T-test was used for analysis