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Fig. 5 | Immunity & Ageing

Fig. 5

From: Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna

Fig. 5

Presence of IgM+ astrocytes. A Representative section of zone 2 from a 12-month-old SAMP8 mouse immunostained with anti-GFAP (green), and IgM (red) antibodies (A); note that astrocytes not close to the fissures were IgM− (green-stained, empty arrowheads, A.1) while only the astrocytes closest to the fissures were IgM+ (yellow (green + red)-stained, full arrowheads, A.2). B Effect of the preadsorption of IgM antibodies with a 0.4 M sugar mixture in IgM+ astrocytes in a representative section of a 12-month-old SAMP8 mouse. C Effect of the pre-treatment with 200 U/mL of ƴ-amylase on the staining with IgM in IgM+ astrocytes in a representative section of a 12-month-old SAMP8 mouse. D Effect of a 40 min boiling pre-treatment on the staining with IgM in IgM+ astrocytes in a representative section of a 12-month-old SAMP8 mouse. Scale bars: 100 µm

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Immunity & Ageing

ISSN: 1742-4933

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