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Table 1 Comparison of the characteristics of EP granules and PAS granules

From: Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna

 

EP granules

PAS granules

Localization

Longitudinal fissure, quadrigeminal cistern and fissura magna

Hippocampusa; piriform cortex, entorhinal cortex, olfactory bulb, cerebellum and trapezoid body

Astrocytic association

-

 + 

Fibroblast association

 + 

-

PAS staining

-

 + 

Presence of p62

-

 + 

Presence of GS

-

 + 

Reactive to IgM

 + 

 + 

Glucidic neoepitopes

 + 

 + 

Sensitivity to γ-amylase

low

high

Sensitivity to boiling treatment

 + 

 + 

  1. Granule characteristics are indicated as positive ( +) or negative (-)
  2. aPredominant region