Fig. 2

MCC950 attenuated caspase-1 mediated inflammatory signal in aging mice. A Sample images show aged caspase-1 activation reporter mouse (22–24 months old) bioluminescence signals before and after MCC950 treatment. MCC950 was treated within 24 h prior to the second imaging session. The analyzed ROIs (red circles) were quantified across both time points. B Significantly elevated head, abdominal, and paw caspase-1 activation associated signals in aged mice and significantly decrease post MCC950 treatment. n = 5 mice per group; *p