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Fig. 5 | Immunity & Ageing

Fig. 5

From: Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages

Fig. 5

Response of young and old BMDMs to young and old mouse plasma

(a) Experimental timeline. At D7 BMDMs were stimulated with young mouse plasma (Y_PL) or old mouse plasma (O_PL) for 24 h. (b) Log2fc of gene expression changes in Y_BMDMs following treatment with Y_PL (white bars) or O_PL (green bars), compared to naive (PBS-treated) Y_BMDMs. Significant changes after Y_PL are shown by an asterisk (*) and changes with O_PL are shown by hash (#). Comparisons of Y_PL vs. O_PL are shown by $. (c) Log2fc of O_BMDMs treated with Y_PL or O_PL. (d) Volcano plot showing comparison of O_ and Y_BMDMs treated with Y_PL. (e) Volcano plot showing comparison of O_ and Y_BMDMs treated with O_PL. Data points show separate BMDM samples, bar heights show the mean and error bars show the standard error of the mean. For all comparisons * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001, **** = P ≤ 0.0001

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Immunity & Ageing

ISSN: 1742-4933

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