Table 1 Characteristics of the study population based on IgM quartiles at baseline
Variable | Overall | Q1[0.168,0.708) | Q2[0.708,1.020) | Q3[1.020,1.400) | Q4[1.40,4.540] | P |
|---|---|---|---|---|---|---|
N | 906 | 227 | 226 | 226 | 227 | |
Age, years | 102.00 (101.00, 104.00) | 102.00 (101.00, 104.00) | 102.00 (101.00, 105.00) | 102.00 (101.00, 104.00) | 102.00 (101.00, 104.00) | 0.713 |
Female, % | 736 (81.20) | 175 (77.10) | 176 (77.90) | 185 (81.90) | 200 (88.10) | 0.010 |
Follow-up time, months | 30.10 (14.80, 53.22) | 26.00 (12.85, 44.85) | 30.95 (12.30, 55.68) | 30.85 (16.42, 50.03) | 32.90 (16.00, 58.45) | 0.022 |
Death, % | 838 (92.50) | 219 (96.50) | 208 (92.00) | 211 (93.40) | 200 (88.10) | 0.008 |
Ethnicity | 0.866 | |||||
Han, % | 804 (88.70) | 203(89.40) | 201(88.90) | 202(89.40) | 198(87.20) | |
Other, % | 102 (11.30) | 24 (10.60) | 25 (11.10) | 24 (10.60) | 29 (12.80) | |
Marital status | 0.847 | |||||
Married, % | 96(10.60) | 27(11.90) | 24(10.60) | 21(9.30) | 24(10.60) | |
Separation/Divorce/Widowhood, % | 810 (89.40) | 200 (88.10) | 202 (89.40) | 205 (90.70) | 203 (89.40) | |
Education | 0.024 | |||||
No education, % | 824 (90.90) | 204 (89.90) | 203 (89.80) | 203 (89.80) | 214 (94.30) | |
Elementary school, % | 63 (7.00) | 12 (5.30) | 19 (8.40) | 20 (8.80) | 12 (5.30) | |
Junior high school and above, % | 19 (2.10) | 11 (4.80) | 4 (1.80) | 3 (1.30) | 1 (0.40) | |
Smoke | 0.332 | |||||
Never, % | 806 (89.00) | 202 (89.00) | 206 (91.20) | 193 (85.40) | 205 (90.30) | |
Past, % | 68 (7.50) | 18 (7.90) | 14 (6.20) | 19 (8.40) | 17 (7.50) | |
Now, % | 32 (3.50) | 7 (3.10) | 6 (2.70) | 14 (6.20) | 5 (2.20) | |
Drinking | 0.392 | |||||
Never, % | 746 (82.30) | 187 (82.40) | 188 (83.20) | 178 (78.80) | 193 (85.00) | |
Past, % | 71 (7.80) | 16 (7.00) | 21 (9.30) | 22 (9.70) | 12 (5.30) | |
Now, % | 89 (9.80) | 24 (10.60) | 17 (7.50) | 26 (11.50) | 22 (9.70) | |
Hypertension, % | 670 (74.00) | 164 (72.20) | 173 (76.50) | 163 (72.10) | 170 (74.90) | 0.653 |
Diabetes mellitus, % | 82 (9.10) | 24 (10.60) | 22 (9.70) | 21 (9.30) | 15 (6.60) | 0.488 |
Coronary heart disease, % | 40 (4.40) | 12 (5.30) | 11 (4.90) | 12 (5.30) | 5 (2.20) | 0.267 |
Body mass index, kg/m2 | 18.15 (16.22, 20.08) | 18.59 (16.42, 20.11) | 18.04 (16.35, 20.00) | 17.90 (16.05, 20.10) | 17.86 (16.04, 19.81) | 0.427 |
IgM, g/L | 1.02 (0.71, 1.40) | 0.56 (0.46, 0.64) | 0.87 (0.78, 0.94) | 1.19 (1.10, 1.28) | 1.72 (1.52, 1.94) | < 0.001 |
IgM Categories | < 0.001 | |||||
Low group (< 0.4 g/L), % | 34 (3.80) | 34 (15.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | |
Normal group (0.4–2.3 g/L), % | 845 (93.30) | 193 (85.00) | 226 (100.00) | 226 (100.00) | 200 (88.10) | |
High group (> 2.3 g/L), % | 27 (3.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 27 (11.90) | |
IgG, g/L | 15.70 (13.60, 18.10) | 15.20 (12.90, 17.75) | 15.50 (13.63, 1775.00) | 15.70 (13.60, 18.20) | 16.40 (14.30, 18.60) | < 0.001 |
IgG Categories | 0.059 | |||||
Normal group (7–16 g/L), % | 469(51.80) | 131(57.70) | 118(52.20) | 118(52.20) | 102(44.90) | |
High group (> 16 g/L), % | 437 (48.20) | 96 (42.30) | 108 (47.80) | 108 (47.80) | 125 (55.10) | |
IgA, g/L | 3.33 (2.53, 4.25) | 3.36 (2.54, 4.17) | 3.32 (2.62, 4.14) | 3.33 (2.46, 4.29) | 3.33 (2.55, 4.31) | 0.995 |
IgA Categories | 0.700 | |||||
Normal group (0.7–4 g/L), % | 628(69.30) | 163(71.80) | 158(69.90) | 151(66.80) | 156(68.70) | |
High group (> 4 g/L), % | 278 (30.70) | 64 (28.20) | 68 (30.10) | 75 (33.20) | 71 (31.30) | |
IgE, IU/mL | 273.00 (81.50, 814.75) | 264.00 (72.50, 698.00) | 308.50 (97.25, 973.75) | 293.00 (95.75, 878.50) | 198.00 (68.00, 703.50) | 0.184 |
IgE Categories | 0.242 | |||||
Normal group (0-100 IU/mL), % | 256(28.30) | 69(30.40) | 57(25.20) | 57(25.20) | 73(32.20) | |
High group (> 100 IU/mL), % | 650 (71.70) | 158 (69.60) | 169 (74.80) | 169 (74.80) | 154 (67.80) | |
LnIgE | 5.56 ± 1.64 | 5.41 ± 1.60 | 5.69 ± 1.68 | 5.66 ± 1.61 | 5.48 ± 1.64 | 0.177 |
C3, g/L | 0.98 (0.86, 1.11) | 0.99 (0.87, 1.12) | 0.97 (0.85, 1.08) | 0.97 (0.86, 1.10) | 1.00 (0.86, 1.16) | 0.308 |
C4, g/L | 0.23 (0.19, 0.28) | 0.23 (0.19, 0.29) | 0.22 (0.18, 0.27) | 0.23 (0.19, 0.29) | 0.23 (0.18, 0.29) | 0.178 |
Kappa, g/L | 4.13 (3.54, 4.78) | 4.01 (3.42, 4.67) | 4.12 (3.54, 4.71) | 4.14 (3.58, 4.73) | 4.30 (3.65, 5.01) | 0.011 |
Lambda, g/L | 2.09 (1.78, 2.49) | 2.04 (1.72, 2.38) | 2.03 (1.78, 2.35) | 2.09 (1.80, 2.52) | 2.21 (1.86, 2.65) | < 0.001 |