The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study

Table 3 Logistic regression of MetS (Non-met as reference group) and components of MetS with prevalence of Frailty at baselines (N = 11,552)

	Model 1			Model 2			Model 3			Model 4
	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
MetS	1.5	1.34–1.67	< 0.001	1.47	1.31–1.65	< 0.001	1.40	1.25–1.57	< 0.001	1.37	1.22–1.53	< 0.001
Components of MetS
Abdominal obesity (Europids)	1.18	1.03–1.36	0.02	1.16	1.00-1.33	0.04	1.10	0.95–1.27	0.2	1.09	0.95–1.26	0.2
Raised TG	1.29	1.13–1.47	< 0.001	1.26	1.11–1.44	0.001	1.20	1.05–1.37	0.006	1.19	1.04–1.36	0.01
Reduced HDL-C	1.37	1.19–1.57	< 0.001	1.36	1.18–1.57	< 0.001	1.29	1.11–1.48	0.001	1.26	1.09–1.46	0.001
Elevated BP	1.57	1.41–1.74	< 0.001	1.57	1.41–1.74	< 0.001	1.54	1.38–1.72	< 0.001	1.50	1.35–1.68	< 0.001
Raised FPG	1.33	1.19–1.49	< 0.001	1.28	1.15–1.44	< 0.001	1.24	1.11–1.40	< 0.001	1.23	1.10–1.38	< 0.001

* Model 1 adjusted for age, sex; model 2, model 1 adjusted for education and living alone; model 3, model 2 adjusted for smoking status, MVPA < 150 min/week, sleep duration, alcohol consumption, and LLDS; model 4, model 3 adjusted for presence of presence of stroke, cancer, CKD, and lung diseases
† MetS: metabolic syndrome; OR: odds ratio; CI: confidence interval; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; BP: blood pressure; FPG: fasting plasma glucose; MVPA: Non-occupational moderate-to-vigorous physical activity; LLDS: Lifelines diet score; CKD: chronic kidney disease

ISSN: 1742-4933