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Fig. 7 | Immunity & Ageing

Fig. 7

From: Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation

Fig. 7

HFD induces senescence markers and SASP cytokines in the liver of WT and Mir146a-/- mice. qPCR analysis of (A) p16 mRNA expression, (B) p21 mRNA expression and (C-E) RT-qPCR analysis of SASP cytokines: Il18, Tnf, and Il6 in the liver of WT and Mir146a-/- mice on HFD and LFD. Number of animals = 5. Data panels (A, C, D, E) were analyzed using two-way ANOVA with Tukey’s multiple comparisons test, data in panel (B) did not pass normality test and transformed into logarithms (Y = log(Y) and further processed using one-way ANOVA with Tukey’s multiple comparisons test. Data are represented as mean ± SEM; * p < 0.05, ** p < 0.01

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Immunity & Ageing

ISSN: 1742-4933

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