Fig. 6

Heat maps showing the correlations between the viral responses and the different T lymphocytes subpopulations distribution. Vertical columns represent the different types of cellular or humoral responses (labelled at the bottom). Horizontally are represented T lymphocyte subpopulations (labeled on the left); for each subpopulation the upper line is expressed as a percentage while the bottom line is expressed as absolute values in cells/µL. The correlation scale (Spearman correlation coefficients) is represented in a greyscale from darker (negative correlation) to lighter (positive correlation). An asterisk indicates a statistically significant correlation (Spearman correlation, p < 0.05) while two asterisks indicate a highly statistically significant correlation (Spearman correlation, p < 0.01). (A) Correlations of responses with the different T lymphocyte subpopulations according to their differentiation stage (naïve-memory). The subpopulations indicated on the left on a light background correspond to the least differentiated subpopulations while on a dark background to the most differentiated for both CD4⁺ and CD8⁺ T lymphocytes. Percentages are referred to the total CD4⁺ or CD8⁺ T lymphocytes but in the case of subtypes of EM they are referred to CD4⁺EM or CD8⁺EM. (B) Correlations of responses with the different functional differentiation subpopulations of memory CD4⁺ T lymphocytes. Percentages are referred to the memory CD4⁺ T lymphocytes