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Fig. 6 | Immunity & Ageing

Fig. 6

From: Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis

Fig. 6

Immune cell infiltration and its relationships with mitochondria-related DEGs in colonic tissues from adult- and elderly-onset UC. a. The heatmap illustrating the proportions of different immune cells in each sample. Each row represents a sample, and each column represents a type of immune cell. The different color indicated the ratio of specific immune cell in this sample. Activated mast cells, resting CD4+ memory T cells, M0 macrophages, M1 macrophages, CD8.+ T cells, plasma cells, neutrophils were the main infiltrating immune cells in the elderly UC. b. The boxplot showing the comparisons of immune cell profiles between adult- and elderly-onset UC tissues using the Wilcoxon test. c. The stacked bar plot illustrating the composition of 22 immune cell subsets in each sample. d. The correlation heatmap between the proportions of infiltrating immune cells and the 30 mDEGs expression in the adult- and elderly-onset UC group using Spearman’s correlation analysis. Red indicated the positive correlation and blue indicated the negative correlation. Both N = 3 in the adult- and elderly-onset UC group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Immunity & Ageing

ISSN: 1742-4933

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