Fig. 14
Three days ingestion of high fat diet (HFD) moderately shifts colon microbiome composition independent of age. A Alpha-diversity indices as measured by Faith’s PD. B Four top bacterial taxa (represented as % total bacteria) upregulated (Lactococcus, Colidextribacter) and downregulated (Lachnospiraceae UCG-006, Prevotellaceae NK3B31) by HFD independent of age. C Two factor negative binomial (NEGBIN) does not indicate a significant age x diet interactions for bacterial taxa. D Heatmap representing Spearman correlation coefficients comparing bacterial genera abundance vs. brain region protein levels in the aged group. * p < 0.05, **p < 0.01, ****p < 0.0001