Fig. 2

Measures of anxiety-like behavior via the open field test (OFT) in young and aged rats following long- and short-term HFD consumption. Percentage of time spent in center during OFT following (A) long and (E) short-term HFD consumption. Percentage of time spent freezing during OFT following (B) short and (F) long-term HFD consumption. The number of rearing episodes during the OFT following (C) long and (G) short-term HFD consumption. Representative plots of routes traced during OFT following (D) long and (H) short-term HFD consumption. *p < 0.05; **p < 0.01; *** p < 0.001; ****p < 0.0001