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Fig. 2 | Immunity & Ageing

Fig. 2

From: Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging

Fig. 2

Lack of secreted IgM leads to enhanced age-related retinal degeneration. (A) Retinas from aged WT and µs-/- mice were fixed, sectioned, and then underwent H&E; RPE: retinal pigment epithelium, OS: outer segments, ONL: outer nuclear layer, INL: inner nuclear layer, GCL: ganglion cell layer. (B) Total retina thickness was quantified from OS to GCL. (C) ONL thickness, (D) INL thickness, and (E) GCL cell count were all measured as presented in material and methods. (F) Retinas from aged WT and µs-/- were fixed, sectioned, and then underwent IHC for Thy1.2 (RGC marker) to visualize loss of GCL density as measured in (E). Results are based on two independent experiments with each data point representing the final average for each measurement for one animal as described in the materials and methods. Aged WT: n = 6. Aged µs-/-: n = 6. Statistics used: Mann-Whitney. *p < 0.05,**p < 0.01. Scale bar = 50 μm

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Immunity & Ageing

ISSN: 1742-4933

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