Table 3 Associations between 16 cell subsets of lymphocytes and health outcomes of chronic disease index, self-reported health, and frailty level
Chronic disease index (range: 0 to 8) | |||
|---|---|---|---|
Predictors | Model 1 | Model 2 | Model 3 |
TCD4N | -0.143 (-0.22, -0.11) | -0.185 (-0.31, -0.16) | -0.17 (-0.24, -0.11) |
TCD4CM | 0.078 (0, 0.2) | 0.133 (0.07, 0.24) | 0.095 (0.02, 0.2) |
TCD4EM | 0.013 (0, 0.02) | 0.002 (-0.01, 0.01) | -0.003 (-0.02, 0) |
TCD4TDEM | 0 (-0.04, 0.02) | 0 (-0.04, 0.02) | -0.012 (-0.05, 0) |
TCD4O | 0.106 (0.07, 0.18) | 0.088 (0.05, 0.17) | 0.103 (0.06, 0.17) |
TCD8N | -0.064 (-0.12, -0.02) | 0 (0, 0.07) | 0 (-0.04, 0.02) |
TCD8CM | 0.142 (0.09, 0.22) | 0.068 (0.02, 0.15) | 0.103 (0.04, 0.18) |
TCD8EM | 0.012 (0, 0.03) | 0.01 (0, 0.02) | 0.01 (0, 0.03) |
TCD8TDEM | 0 (-0.03, 0.06) | 0 (-0.02, 0.05) | 0 (0, 0.05) |
TCD8O | -0.221 (-0.32, -0.18) | -0.133 (-0.25, -0.1) | -0.145 (-0.23, -0.09) |
TO | 0 (0, 0.07) | 0 (0, 0.07) | 0 (0, 0.06) |
BN | 0 (-0.1, 0) | 0.01 (0, 0.07) | 0.038 (0, 0.09) |
BMIgD- | -0.025 (-0.14, 0) | 0 (-0.09, 0) | 0 (-0.07, 0) |
BMIgD+ | -0.091 (-0.13, -0.03) | -0.053 (-0.12, -0.02) | -0.089 (-0.14, -0.04) |
BO | 0.082 (0.04, 0.21) | 0.059 (0.02, 0.13) | 0.032 (0, 0.1) |
LYMPO | 0.112 (0.06, 0.17) | 0 (0, 0.08) | 0.038 (0, 0.1) |
Age | - | 0.037 (0.03, 0.04) | 0.035 (0.03, 0.04) |
Gender: Female | - | 0.145 (0.08, 0.23) | 0.126 (0.06, 0.2) |
Race: Black | - | - | 0.254 (0.14, 0.36) |
Race: Hispanic | - | - | -0.175 (-0.31, -0.06) |
Race: Other | - | - | 0.05 (-0.13, 0.31) |
Education: Lower secondary | - | - | 0.317 (0.14, 0.53) |
Education: Upper secondary | - | - | -0.079 (-0.23, 0.12) |
Education: Above upper secondary | - | - | -0.246 (-0.4, -0.05) |
CMV: Reactive | - | - | 0.078 (-0.01, 0.18) |
Intercept | 2.442 (2.17, 2.68) | -0.071 (-0.46, 0.23) | -0.059 (-0.55, 0.37) |
Self-reported health (range: 1 to 5) | |||
Predictors | Model 1 | Model 2 | Model 3 |
TCD4N | -0.142 (-0.17, -0.06) | -0.152 (-0.18, -0.06) | 0 (-0.1, 0) |
TCD4CM | 0.035 (0, 0.11) | 0.04 (0, 0.1) | 0 (0, 0.05) |
TCD4EM | 0.016 (0.01, 0.02) | 0.015 (0.01, 0.02) | 0 (0, 0.01) |
TCD4TDEM | 0.012 (0, 0.03) | 0.01 (0, 0.03) | 0 (-0.02, 0.01) |
TCD4O | 0.075 (0, 0.11) | 0.075 (0.02, 0.1) | 0 (0, 0.09) |
TCD8N | 0.024 (0, 0.05) | 0.027 (0, 0.05) | 0 (-0.01, 0) |
TCD8CM | 0.044 (0, 0.08) | 0.044 (0, 0.08) | 0 (0, 0.1) |
TCD8EM | 0 (-0.01, 0.01) | 0 (-0.01, 0.01) | 0 (-0.01, 0.01) |
TCD8TDEM | 0 (-0.01, 0.03) | 0 (-0.01, 0.03) | 0 (0, 0.04) |
TCD8O | -0.101 (-0.14, 0) | -0.097 (-0.14, 0) | 0 (-0.1, 0) |
TO | 0 (-0.04, 0) | 0 (-0.04, 0.01) | 0 (-0.03, 0) |
BN | -0.016 (-0.06, 0) | -0.016 (-0.06, 0) | 0 (-0.06, 0) |
BMIgD- | 0 (-0.02, 0.03) | 0 (-0.02, 0.02) | 0 (-0.04, 0) |
BMIgD+ | -0.033 (-0.07, 0) | -0.035 (-0.07, 0) | 0 (-0.07, 0) |
BO | 0.036 (0, 0.07) | 0.035 (0, 0.07) | 0 (0, 0.05) |
LYMPO | 0.048 (0, 0.08) | 0.053 (0, 0.08) | 0 (0, 0.09) |
Age | - | 0.002 (0, 0) | 0.005 (0, 0.01) |
Gender: Female | - | 0.073 (0.01, 0.13) | 0.02 (-0.02, 0.1) |
Race: Black | - | - | 0.3 (0.21, 0.38) |
Race: Hispanic | - | - | 0.311 (0.22, 0.38) |
Race: Other | - | - | 0.331 (0.21, 0.48) |
Education: Lower secondary | - | - | -0.068 (-0.18, 0.05) |
Education: Upper secondary | - | - | -0.35 (-0.45, -0.23) |
Education: Above upper secondary | - | - | -0.604 (-0.69, -0.49) |
CMV: Reactive | - | - | 0.047 (-0.05, 0.08) |
Intercept | 3.098 (2.93, 3.23) | 2.929 (2.66, 3.13) | 2.806 (2.58, 3.16) |
Frailty level (range: 1 to 4) | |||
Predictors | Model 1 | Model 2 | Model 3 |
TCD4N | -0.126 (-0.17, -0.08) | -0.175 (-0.24, -0.14) | -0.115 (-0.14, -0.06) |
TCD4CM | 0.044 (0, 0.13) | 0.081 (0.01, 0.17) | 0.035 (0, 0.1) |
TCD4EM | 0.021 (0.01, 0.03) | 0.014 (0, 0.02) | 0.003 (-0.01, 0.01) |
TCD4TDEM | 0.013 (0, 0.04) | 0.011 (0, 0.03) | -0.011 (-0.03, 0.01) |
TCD4O | 0.117 (0.07, 0.16) | 0.104 (0.06, 0.15) | 0.113 (0.06, 0.14) |
TCD8N | -0.019 (-0.05, 0) | 0.02 (0, 0.06) | 0 (-0.02, 0) |
TCD8CM | 0.103 (0.05, 0.14) | 0.058 (0.02, 0.1) | 0.102 (0.04, 0.13) |
TCD8EM | 0 (-0.01, 0.01) | 0 (-0.01, 0.01) | 0.001 (-0.01, 0.01) |
TCD8TDEM | 0 (-0.03, 0.03) | 0 (-0.03, 0.03) | 0 (0, 0.03) |
TCD8O | -0.211 (-0.26, -0.15) | -0.141 (-0.2, -0.1) | -0.144 (-0.17, -0.07) |
TO | 0 (-0.05, 0.02) | 0 (-0.02, 0.03) | 0 (-0.01, 0.02) |
BN | -0.042 (-0.1, 0) | 0 (-0.05, 0.02) | 0 (-0.03, 0.02) |
BMIgD- | 0 (-0.06, 0.02) | 0 (0, 0.03) | 0 (-0.02, 0.02) |
BMIgD+ | -0.051 (-0.08, -0.01) | -0.035 (-0.08, 0) | -0.06 (-0.09, -0.02) |
BO | 0.09 (0.05, 0.16) | 0.063 (0.03, 0.1) | 0.041 (0, 0.07) |
LYMPO | 0.058 (0.01, 0.1) | 0 (0, 0.05) | 0.036 (0, 0.06) |
Age | - | 0.025 (0.02, 0.03) | 0.023 (0.02, 0.03) |
Gender: Female | - | 0.253 (0.19, 0.3) | 0.23 (0.17, 0.28) |
Race: Black | - | - | 0.3 (0.23, 0.38) |
Race: Hispanic | - | - | 0.07 (-0.02, 0.17) |
Race: Other | - | - | 0.117 (-0.02, 0.27) |
Education: Lower secondary | - | - | 0.076 (-0.05, 0.19) |
Education: Upper secondary | - | - | -0.264 (-0.38, -0.16) |
Education: Above upper secondary | - | - | -0.552 (-0.66, -0.44) |
CMV: Reactive | - | - | 0.089 (0.02, 0.14) |
Intercept | 2.587 (2.41, 2.74) | 0.773 (0.51, 0.96) | 0.867 (0.57, 1.11) |