Table 1 Zinc transporters and their immunological relevance

ZnT1

Ubiquitous

-

[51]

ZnT2

Widely expressed

Mutations lead to low zinc in maternal milk and thereby neonatal zinc deficiency (humans only)

[52, 53]

ZnT3

Brain

-

[54, 55]

ZnT4

Ubiquitous

Lethal milk mutant leads to less zinc in milk and neonatal zinc deficiency (mice only, human ZnT2)

[56]

ZnT5

Ubiquitous

Loss of function leads to impaired mast cell function

[57]

ZnT6

Widely expressed

-

ZnT7

Widely expressed

-

[58, 59]

ZnT8

Pancreas

Autoantigen in type I diabetes mellitus

[60]

ZnT9

Brain, muscle kidney

-

[61]

ZnT10

Small intestine, liver, brain

-

[62, 63]